A key resource, year after year, is Access Medicine with all those online books. Here's a quick link to it.
But if it does not have what you need, perhaps these other texts will help.
As you have learned, a patient's family medical history is often an important piece of the puzzle. The Surgeon General's office has created a secure online tool for patients to organize and explore their own family medical history and Ohio State University Medical Center has a handy PDF to help sketch out the history.
Resources for this case include:
Textbook Suggestions (look left)
Key Textbooks - regarding Thallassemia
National Organizations - Be the Match: Clinical
PubMed Search Tips -- Ethics & Genetics Literature
Be the Match
This is an interesting national organization that has both patient and physician level information. Their Bioinformatics section - especially their HLA resources - might be particularly informative.
A couple resources that might be familiar to you. These are great resources for medical topics of various types and each has its own strengths. Check out thalassemia or preimplantation genetic diagnosis in either one. eMedicine requires creating a free account, but is worth the extra step.
1) Ethics Literature
PubMed has some good articles about the ethical situation of preimplantation genetic diagnosis and having a child as a rescue for a child with thalassemia. A simple search (I used the terms preimplantation genetic diagnosis AND tissue donor) along with the filter for Bioethics gives a nice set of articles. (Find the filter for Bioethics by clicking "Show Additional Filters" on the left side and adding the "Subjects" group. Bioethics is one of the options under Subjects.)
An alternate search is to use the mesh term or rather major mesh heading of preimplantation genetic diagnosis paired with a subheading of ethics, as in
preimplantation genetic diagnosis/ethics[majr]
You will find a great discussion has been occurring regarding this topic in the past couple of years.
|Example Citations from Bioethics Filter Search & the MeSH Search with a Subheading|
|There is some overlap with each search but also some unique items.that each will retrieve.|
2) Medical Genetics Literature
For molecular genetics articles in PubMed, they may be a little tricky to zone in on just the articles you want or to really find what you need. For example, if you wanted articles on preimplantation genetic diagnosis AND thalassemia AND molecular genetics, your results in PubMed would be less than 20, but I know there are more than that. One quick solution to getting some on-target, very relevant articles is to use PubMed's Clinical Queries tool. You'll find it right on the front page of PubMed.
Next, type in your search terms - this time, just use preimplantation genetics AND thalassemia major (with or without the AND) and once you see the results, set the selection box to "Molecular Genetics".
This search will give you over 70 articles and many of them seem to be relevant.