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Resources for this case include:
Textbook Suggestions (look left)
Featured Resources: ACP Journal Club
PubMed Search Tips -- Quickly Getting to the Evidence on Treatment
Two key textbooks for the background on RA are Harrison's & Cecil Medicine.
A very nice section on RA and it signs, symptoms, & manifestations.
Check out the section on RA for details on epidemiology, genetic factors, clinical course, & more.
ACP Journal Club
Now that you have finished EBMI, you can see how this resource is unique and very valuable for drilling down to the Number Needed to Harm or Number Needed to Treat. It does not cover all topics, yet, so you have to be selective about the topics you search there - primarily internal medicine topics, but if it has the answer you need, you're a head of the game. Try it out. (Remember, with synthesized resources, limit to to most important terms because their depth is not as great as PubMed's.)
Perhaps this week, one topic to try is rheumatoid arthritis. See what develops - perhaps an analysis of a very recent Cochrane systematic review on RA.
Quick comment about the search - be sure to use the box for the Journal Club and not the top search box which searches the entire site.
You might find some info on rituximab & methotrexate or TNF.
National & Government Organizations
Guidelines and concensus statements, while not always a systematic review, review the existing literature and are considered a high level of evidence.
This week, the key organization to know is the American College of Rheumatology. It provides resources for health professional education and research including publishing guidelines on treatment & diagnosis.
Find the Evidence about Treatment #2
Find the Evidence about Treatment #3
Some of your questions for this case include better understanding of the medications used or potentially used. This information could come from a variety of resources, from textbooks to Google searches. However, the following two resources have the seal of approval from the UCSD Healthcare System. It is a good idea to get used to using one of them.
In either of these resources look up information by specific drug (e.g., salsalate or rantidine or adverse effects of steroids) or use the disease to find a list of drugs for that diagnosis (Micromedex).
Looking up information about the results of lab tests are mostly background questions. The following resources are easy to use tools to find very reliable information about the normal values, reference ranges, and more.
Need to work on the DDX for the case? Symptoms and differential diagnostic information is often buried in a number of our resources. However, a few tools (both online and for your smart phone/PDA) have special tools to help with this process.
The books we have include one that helps explain the thinking process (Symptom to Diagnosis) with topics that include a variety of non-specific complaints from low back pain to weight loss to GI bleeding, to abdominal pain. One book has a list of mnemonics (Collins' book) as well as the symptom info. Another book (Syed & Rasul's book) is organized by body areas and the last one (DDX of Common Complaints) focuses on the most common symptions and presents the way a doctor might pursue to diagnosis (images & tests).
Also listed below are some of the interactive DDX tools and their advantages.
Online Look-up Tools
The two point of care tools - eMedicine and Up to Date each have some unique things for this case. Up to Date has a great DDX list and eMedicine has some histology images.