| BTAI | Behavioral Threat Assessment Integration | unable to verify |
| CLEAR | Clean Lakes, Estuaries, and Rivers Initiative | unable to verify |
| NCHM | Health Communication and Social Marketing | changed to Health Communication |
| OBIMO | Office of Bioresearch Monitoring Operations | changed to OBMI - Office of Bioresearch Monitoring Inspectorate |
| OCLiP | Office of Clinical Policy | changed to OCLP - same name |
| OCPP | Office of Clinical Policy and Programs | unable to verify |
| OHPI | Office of Highway Policy Information | changed to HPPI - same name |
| OIPD | Office of Innovative Program Delivery | changed to Office of Performance and Innovative Finance Support - no acronym |
| OMDRHO | Office of Medical Device and Radiological Health Operations | changed to OMDRHI - Office of Medical Device and Radiological Health Inspectorate |
| ORA | Office of Regulatory Affairs | changed to OII - Office of Inspections and Investigations |
| OSI | Office of Scientific Integrity | unable to verify; likely merged into OPHER - Office of Public Health Ethics and Regulations |
| OSQ | Office of Science Quality | changed to OSQLS - Office of Science Quality and Library Services |
| OTI | Office of Technology and Innovation | changed to TTO - Technology Transfer Office |
| PRC VCN | Prevention Research Centers Vaccine Confidence Network | unable to verify |
| STARS | Spatial Tools for the Analysis of River Systems | unable to verify |
| UxSRTO | Uncrewed Systems Research Transition Office | terminated |
