| AGNPS | Agricultural Non-Point Source Pollution Model | unable to verify |
| AMO | Advanced Manufacturing Office | split into AMMTO (Advanced Materials and Manufacturing Technologies Office) and IEDO (Industrial Efficiency and Decarbonization Office) |
| AWEP | Agricultural Water Enhancement Program | unable to verify |
| AWTP | Advanced Wireless Test Platforms | unable to verify |
| CMU | Crisis Management Unit | unable to verify |
| CPGL | Conservation of Private Grazing Land | unable to verify |
| DART | Developmental and Reproductive Toxicology Database | unable to verify |
| EHR | Directorate for Education and Human Resources | changed to EDU - Directorate for STEM Education |
| EWPP | Emergency Watershed Protection Program | changed to EWP - same name |
| FAVIR | Fruits and Vegetables Import Requirements Database | replaced by ACIR - Agricultural Commodity Import Requirements |
| FBE | Foreign Biometric Exchange Program | unable to verify |
| FRPP | Farm and Ranch Lands Protection Program | unable to verify |
| FSIMS | Flight Standards Information Management System | decommissioned; replaced by DRS - Dynamic Regulatory System |
| GRAIL | Gaseous Radioisotope Analysis In Situ Laboratory | unable to verify |
| MT&D | Marine Trash and Debris | changed to Marine Debris Program (no acronym) |
| NGCE | National Geospatial Center of Excellence | unable to verify |
| NTER | National Training and Education Resource | unable to verify |
| OCRWM | Office of Civilian Radioactive Waste Management | unable to verify |
| OEHRM | Office of Electronic Health Record Modernization | changed to VA EHRM Integration Office (no acronym) |
| RGL | Regulatory and Guidance Library | decommissioned; replaced by DRS - Dynamic Regulatory System |
| RISA | Regional Integrated Sciences & Assessments | changed to CAP/RISA - Climate Adaptation Partnerships/Regional Integrated Sciences & Assessments |
| SWSI | Surface Water Supply Index | unable to verify |
| WHIP | Wildlife Habitat Incentive Program | unable to verify |
| WRP | Wetlands Reserve Program | unable to verify |
