| HS&B |
High School & Beyond |
| HSAC |
Homeland Security Advisory Council |
| HSARPA |
Homeland Security Advanced Research Projects Agency (older link archive) |
| HSAS |
Homeland Security Advisory System (replaced by NTAS) |
| HSB |
Head Start Bureau (changed to OHS) | Health Studies Branch | Healthcare Systems Bureau |
| HSDL |
Homeland Security Digital Library |
| HSEB |
Health Services and Economics Branch (replaced by HARB) |
| HSEEP |
Homeland Security Exercise and Evaluation Program (older link archive) |
| HSGAC |
U.S. Senate Committee on Homeland Security & Governmental Affairs |
| HSGI |
High School Graduation Initiative |
| HSGP |
Homeland Security Grant Program |
| HSI |
Hispanic-Serving Institutions Division | Homeland Security Investigations |
| HSIN |
Homeland Security Information Network |
| HSINAC |
Homeland Security Information Network Advisory Committee (unable to verify 11/17) |
| HSIP |
Highway Safety Improvement Program | Homeland Security Infrastructure Program (older link archive) |
| HSIPR |
High-Speed Intercity Passenger Rail Program (older link archive) |
| HSIRB |
Health Systems and Interventions Research Branch |
| HSMMD |
Homeland Security Materials Management Division |
| HSOC |
Homeland Security Operations Center (unable to verify 3/12) |
| HSP |
Office of Human Services Policy |
| HSPC |
Homeland Security Policy Council (older link archive) |
| HSPP |
Human Subjects Protection Program (unable to verify 6/19) |
| HSR |
Health Services Research |
| HSR&D |
Health Services Research & Development |
| HSRB |
Hazardous Substances Research Branch | Human Studies Review Board |
| HSRIC |
Health Services Research Information Central (older link archive) |
| HSS |
Office of Health, Safety and Security (divided into IEA and EHSS 5/14) |
| HSSTAC |
Homeland Security Science and Technology Advisory Committee |
| HST |
High School Transcript Studies |
| HSWG |
Human Subjects Working Group (changed to HSPP) |
| HTF |
Housing Trust Fund | Hypoxia Task Force |
| HTPU |
Human Trafficking Prosecution Unit |
| HTS |
Harmonized Tariff Schedule |
| HUBZone |
Historically Underutilized Business Zones |
| HUD |
Department of Housing and Urban Development (older link archive) | Humanitarian Use Device (older link archive) |
| HUD-VASH |
HUD Veteran Affairs Supportive Housing Program |
| HVRP |
Homeless Veterans Reintegration Program (older link archive) |
| HVS |
Housing Vacancy Survey |
| HVU |
HUD Virtual University (older link archive) |
| HWM |
Health and Wellness Manager |
| HWT |
Hazardous Weather Testbed |
| HyspIRI |
Hyperspectral Infrared Imager |